Red blood cell membrane lipid peroxidation and chronic haemolysis in haemodialysis patients
Taccone-Gallucci, M.; Lubrano, R.; Mazzarella, V.; Bandino, D.; Meloni, C.; Morosetti, M.; Elli, M.; Giardini, O.; Boffo, V.; Tozzo, C.
Life Support Systems the Journal of the European Society for Artificial Organs 3(Suppl 1): 41-44
1985
ISSN/ISBN: 0261-989X PMID: 3870599 Document Number: 264459
Pre dialysis concentrations of malonyldialdehyde (MDA) in the red blood cell membranes and pre and post dialysis percent variation of plasma haemoglobin levels are studied in a group of uraemic patients on maintenance haemodialysis both before and after a therapeutic trial with vitamin E. The findings show a significant correlation between MDA levels and percent variation of plasma haemoglobin during dialysis, thus indicating that reducing the amount of lipid peroxidation can help to reduce intradialytic chronic haemolysis.