Mutagenic activity of the fungicide captan
Pilinskaia, M.A.; Shigaeva, M.K.; Kasinova, G.V.; Malashenko, A.M.; Vyskubenko, I.F.
Tsitologiia i Genetika 18(2): 123-128
1984
ISSN/ISBN: 0564-3783 PMID: 6729989 Document Number: 235729
A complex study of mutagenic activity of captan (a fungicide) in a series of standard test-systems has shown that the preparation induces gene mutations in certain Salmonella indicator strains (without metabolic activation), increases the frequency of mitotic crossing-over and gene conversion in yeasts (Saccharomyces), possesses a weak cytogenetic action on bone marrow cells in experimental animals, manifests no cytogenetic effect in the lymphocyte culture of human peripheral blood (including a system of microsomal activation). Genetic activity of captan cannot be a limiting criterion of its harmfulness.