Top Abstract Purchase Related
Home
>
Node
>
Subnode

Mutagenic activity of isoniazid & its metabolites in different test systems

Menon, M.M.; Maru, G.B.; Bhide, S.V.

Indian Journal of Experimental Biology 19(10): 939-942

1981

ISSN/ISBN: 0019-5189
PMID: 7030934
Document Number: 177406
Possible mutagenic effects of Isoniazid (INH) and its metabolites are evaluated using the Salmonella mammalian microsome assay and 2 other mammalian in vivo tests, namely dominant lethal test and mouse testicular DNA synthesis inhibition test. Isoniazid was mutagenic in 2 of the 4 strains tested by Ames method (TA 100 and TA 1535) in absence of the microsomal fraction (S9). Of the hydrazine metabolites, hydrazine sulfate (HS) and monoacetyl hydrazine (MAH) were mutagenic. Antitoxicants of INH did not show dose dependent inhibition of mutagenic activity of INH. The response of INH and hydrazine was negative in dominant lethal test, whereas DNA synthesis in mouse testis was inhibited by INH, HS, MAH and acetyl INH.

Document emailed within 1 workday
Secure & encrypted payments

Kalinina, L.M.; Polukhina, G.N.; Lukasheva, L.I. 1977: Salmonella typhimurium as a test system for detecting the mutagenic activity of environmental pollutants. I. the mutagenic action of heavy metal salts in in vivo and in vitro systems without metabolic activation Genetika 13(6): 1089-1092
Vasil'eva, S.V.; Makhova, E.V.; Efremenkova, O.V.; Bartoshevich, I.E. 1996: Genotoxic and mutagenic activity of antineoplastic anthracyclines and their aglycones: study in two test-systems Genetika 32(2): 233-239
Arutiunian, R.M.; Zalinian, G.G.; Mugnetsian, E.G.; Gukasian, L.A. 1987: Mutagenic action of latex polymerization stabilizers in various test systems Tsitologiia i Genetika 21(6): 450-454
Dugan, A.M.; Barilyak, I.R. 1995: The evaluation of the mutagenic activity of gaseous particles in the atmospheric air by using a microbiological test Mikrobiolohichnyi Zhurnal 57(4): 66-72
Dugan, A.M. 1994: Salmonella typhimurium as a test system for detecting the mutagenic activity of environmental pollutants Tsitologiia i Genetika 28(3): 37-41
Hsia, M.T.; Lin, F.S.; Allen, J.R. 1978: Comparative mutagenicity and toxic effects of 2,5,2',5'-tetrachlorobiphenyl and its metabolites in bacterial and mammalian test systems Research Communications in Chemical Pathology and Pharmacology 21(3): 485-496
Atoiants, A.L.; Pogosian, V.S.; Agadzhanian, E.A.; Kasparova, I.P.; Arutiunian, R.M. 1996: An evaluation of the mutagenic activity of the air pollutants in the area of a plant for the manufacture of synthetic rubber by using Tradescantia (clone 02) as the test object Tsitologiia i Genetika 30(3): 26-31
Gichner, T.; Velemínský, J. 1987: The organic solvents acetone, ethanol and dimethylformamide potentiate the mutagenic activity of N-methyl-N'-nitro-N-nitrosoguanidine, but have no effect on the mutagenic potential of N-methyl-N-nitrosourea Mutation Research 192(1): 31-35
Warzok, R.; Mendel, J.; Thust, R.; Schwarz, H.; Schneider, J. 1980: Physico-chemical, mutagenic and carcinogenic properties of nitrosated urea herbicide metabolites Iarc Scientific Publications 31: 685-691
Reddy, T.V.; Ramanathan, R.; Benjamin, T.; Grantham, P.H.; Weisburger, E.K. 1986: Effect of microsomal enzyme inducers on the urinary excretion pattern of mutagenic metabolites of the carcinogen 2,4-toluenediamine Journal of the National Cancer Institute 76(2): 291-297
Kawai, T. 1998: Activity of ISO/TC212, clinical laboratory testing and in vitro diagnostic test systems Rinsho Byori. Japanese Journal of Clinical Pathology 46(10): 961-967
Sokolova, K.Ia.; Gurtovnik, A.I.; Zalesskikh, N.V.; Nosov, N.N.; Plugaru, S.V. 1983: Development and evaluation of methods using paper test-systems for the determination of the biochemical activity of Enterobacteriaceae Laboratornoe Delo 1983(9): 55-58
Jia, P.-p.; Zhao, L.-l.; Li, X.-y.; Zhang, Q.; Liu, Z.-l.; Wang, X.; Yu, L.-y.; Zhao, L.-x.; Cen, S. 2011: Establishment and drug susceptibility test of isoniazid resistant Mycobacterium smegmatis Yao Xue Xue Bao 46(4): 377-382
Nair, C.R.; Gupta, R.C.; Varshneya, A.K.; Malik, S.K. 1984: Correlation of sulphadimidine acetylation test in urine and blood for isoniazid phenotyping International Journal of Clinical Pharmacology Therapy and Toxicology 22(12): 646-647
Strizhel'chik, N.G.; Kul'shin, V.E. 1994: The mutagenic and modifying properties of new gelatinous substances studied by using the Ames test Tsitologiia i Genetika 28(3): 91
Lorke, D.; Machemer, L. 1975: Testing mutagenic properties with the dominant lethal test on the male mouse Environmental Quality and Safety. Suppl 4: 239-246
Ioan, D. 1980: The mutagenic effect of carbimazol and methylthiouracil detected by the transplacentar micronucleus test Endocrinologie 18(4): 247-250
Homorodean, D. 2005: A simple enzyme test for proving the resistance to isoniazid of Mycobacterium tuberculosis strains Pneumologia 54(2): 58-61
Fonshteĭn, L.M.; Zolotareva, G.N.; Iskhakova, E.N.; Shapiro, A.A. 1976: Mutagenic activity of benzonal Tsitologiia i Genetika 10(2): 99-102
Alekseenok, A.I. 1992: Mutagenic activity of the plant preparation KAC-81 Tsitologiia i Genetika 26(2): 56-60