Effect of homologous serum globulin preparations on the intestinal automicroflora of mice after irradiation
Pinegin, B.V.; Klemparskaia, N.N.; Mal'tsev, V.N.; Korshunov, V.M.; Shal'nova, G.A.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 9: 61-65
1984
ISSN/ISBN: 0372-9311 PMID: 6506941 Document Number: 232853
In experiments on 4000 noninbred and CBA mice the influence of the injections of alpha-, beta- and gamma-globusin, IgG and IgM, obtained from the sera of hemostimulated and intact mice, on the intestinal microflora after irradiation has been studied. The experiments have revealed that 3 subcutaneous or intraperitoneal injections of 1 mg per mouse, made 2, 24 and 48 hours after the irradiation of the animals with gamma-rays in a dose of 700 r, considerably reduce the intensity of the accumulation of opportunistic bacteria in the small and large intestines, commonly occurring in irradiated animals. A decrease in the number of lactobacteria is less pronounced. The preparations of globulin and IgG obtained from hemostimulated mice, i.e. enriched with normal tissue antibodies, have proved to be most effective.