Effect of piracetam on the resistance of mice to hypoxic hypoxia 2 to 3 months following x-ray irradiation
Popov, A.V.; Bochenkov, A.A.; Ivnitskii, Y.Y.; Volkovskii, Y.V.
Kosmicheskaia Biologiia i Aviakosmicheskaia Meditsina 21(4): 64-66
1987
ISSN/ISBN: 0321-5040 PMID: 3657067 Document Number: 288011
The resistance of mice to hypoxic hypoxia 3 months after their X-irradiation was evaluated with respect to such parameters as survival rate during the "ascent" to 11,000 m, life time at that altitude and brain succinic dehydrogenase (SDH) and lactate dehydrogenase (LDH) activities at an altitude of 7.000 m. Irradiated mice proved to be less resistant to hypoxic hypoxia. SDH activity increased to a greater extent in nonirradiated than in irradiated animals. Pyracetam increased significantly the resistance to hypoxia of both irradiated and nonirradiated mice. SDH activity was stimulated by hypoxia in a greater degree in the pyracetam-treated mice. The resistance to hypoxic hypoxia and SDH activation at an altitude at 7.000 m were found to be closely correlated. LDH activity remained essentially unchanged in any of the animals groups.