Effect of potassium channel openers on lysosomal function and morphology during acute hypoxic hypoxia
Honchar, O.O.; Rozova, K.V.; Seredenko, M.M.
Fiziolohichnyi Zhurnal 47(5): 26-30
2001
ISSN/ISBN: 2522-9028 PMID: 11758463 Document Number: 532291
It was studying the effect of fluorinecontain pinacidil analogs (PF-5 and PF-10), which are the K(+)-channel openers, on morphofunctional lysosomes state at lung and heart tissues. The investigation was made on white pubertal rat-males under acute (30 min) hypoxic hypoxia (7% O2 [symbol: see text] N2). The application of PF-5 and PF-10 under acute hypoxic hypoxia leads in lung and myocardium tissues to morphofunctional changes of lysosome system in investigated cells, which were connected with decreasing of enzyemia. It, partly, may be explain by increasing of connected enzyme forms synthesis, because such forms are the functional latent, so the output of enzymes in blood under unfavourable conditions increased.