Effect of isolation stress on ethanol pharmacodynamics in the blood of rats
Burov, I.V.; Vlasova, N.V.; Rodionov, A.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 98(9): 320-321
1984
ISSN/ISBN: 0365-9615 PMID: 6541514 Document Number: 231807
Head space chromatography was used to study the rate of ethanol excretion as criterion of the activity of the ethanol-oxidizing enzymatic system. Isolational stress was shown to be one of the factors determining induction of the ethanol-oxidizing erzymatic systems. The isolation-induced activity of these systems was reduced by diazepam administration. This fact may evidence the existence of central regulation of the activity of the enzymatic systems that metabolize ethanol.