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The effect of chlorpromazine on pharmacokinetics and pharmacodynamics of phenobarbital in X-irradiated rats

Okulicz-Kozaryn, I.; Wójciakowa, Z.; Godlewski, J.; Nowakowska, E.

Polish Journal of Pharmacology and Pharmacy 36(1): 65-71

1984

ISSN/ISBN: 0301-0244
PMID: 6462962
Document Number: 231459
Male Wistar rats were irradiated with a single 600R dose of X-rays on the whole body. Chlorpromazine was given 30 min before phenobarbital. Phenobarbital sleeping time was prolonged by chlorpromazine both in irradiated and non-irradiated rats. On the 3rd day after irradiation the prolongation of the phenobarbital sleep by chlorpromazine was more marked than on the 6th day. No correlation between the pharmacodynamic action of phenobarbital and its cerebral level was noted.

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