Pharmacokinetics of pueraria flavonoids from Pueraria lobata by anti-oxidant pharmacodynamics effect method
Jia, X.-b.; Cai, Y.; Chen, Y.; Cheng, X.-d.; Fan, C.-y.; Shi, Y.-f.
Zhongguo Zhong Yao Za Zhi 32(22): 2370-2373
2007
ISSN/ISBN: 1001-5302 PMID: 18257261 Document Number: 614010
To study the pharmacokinetics of pueraria flavonoids(PF) from Pueraria lobata. An anti-oxidant pharmacodynamics effect method was quoted to detect the antioxidant ability of PF contained in rats plasm after oral delivered, measures the fluorescence intensity, and calculates the concentration of components in plasma, then we can get the plot of the change of the content of PF contained in rats plasm, and then we can get the pharmacokinetics of Pueraria Flavonoids pellets. The AUC of Pueraria lobata isoflavone pellets is 4.40-fold of Yufengningxin tablets. It can enhance the bioavailability of PF by made it to pellets.