Intracellular hormonal function of acetylcholine and noradrenaline: the regulation of the catalase level in liver cells
Elaev, N.R.; Panova, M.K.; Mikhaĭlova, E.V.; Kharitonova, N.V.
Problemy Endokrinologii 30(3): 69-72
1984
ISSN/ISBN: 0375-9660 PMID: 6739457 Document Number: 230882
The injection of acetylcholine (15 to 150 micrograms/100 g) to rats or preincubation in the hepatic homogenate with acetylcholine (10(-6) to 10(-3) M) induces a decrease in the catalase activity, mainly in its bound form. Acetylcholine effect does not manifest in the presence of actinomycine D and puromycine. Noradrenaline injection to animals (1.5 to 15 micrograms/100 g) or preincubation of the hepatic homogenate with noradrenaline (10(-6) to 10(-3) M) produces a rise of the catalase activity (mainly of its bound form), being blocked by actinomycine D and non-blocked by propranolol. Acetylcholine- and noradrenaline action on the catalase level is not mediated by cyclic nucleotides and may be considered as intracellular hormonal effect.