Hormonal regulation of sodium-fluid balance and some hemodynamic parameters in the rat. I. Effect of indomethacin and vasopressor-vasodepressor hormonal systems in the regulation of blood pressure
Somova, L.; Zaharieva, S.; Ivanova, M.
Acta Physiologica et Pharmacologica Bulgarica 12(2): 27-34
1986
ISSN/ISBN: 0323-9950 PMID: 3766163 Document Number: 273172
A study based on sodium depletion, sodium loading and indomethacin treatment was conducted on rats. After sodium depletion significant activation of renin-angiotensin-aldosterone system and insignificantly increased kallikrein excretion without changes in prostaglandin excretion and plasma vasopressin were found. After sodium loading significant decrease of PRA (-83%), prostaglanding excretion (-34%), insignificantly decrease of aldosterone and kallikrein excretion and significant increase of vasopressin (134%) were established. Indomethacin (5 mg/kg b.w.) administered for 8 days showed an antidiuretic and an anti/natriuretic effect, inhibition of PG-synthesis by 57% and of PRA by 68%, a significant increase of plasma volume (21%), blood volume (24%) and mean arterial pressure (14%). The relationships between vasopressor and vasodepressor hormonal systems in the rat are discussed.