Hormonal and vitamin regulation of glucose-6-phosphatases activity in the liver
Vinogradov, V.V.; Mandrik, K.A.; Ostrovskiĭ, I.M.
Ukrains'kyi Biokhimichnyi Zhurnal 48(4): 421-425
1976
ISSN/ISBN: 0041-610X PMID: 185765 Document Number: 107859
Glucose-6-phosphatase (G-6-Pase) activity in the rat liver correlated directly with the content of corticosteroids in the blood. It decreased with hypocorticoidism (adrenalectomy) and rose with hypercorticoidism (stress). The highest G-6-Pase activity in the liver of the intact animals is observed in autumn, the lowest one in spring, i.e., in the periods when the adrenals function has minimal and maximal values, respectively. Thiamine (0.4 g/kg) caused a decrease in the G-6-Pase activity in the liver of the intact rats and adrenalectomized or hypophysectomized animals. A pronounced insulin-like effect of vitamin B on G-6-Pase activity is connected with an intensified synthesis of the corresponding hormone in the pancreas.