Radioreceptor assay for oxyphenonium
Ensing, K.; de Zeeuw, R.A.
European Journal of Respiratory Diseases. Suppl 135: 143-146
1984
ISSN/ISBN: 0106-4347 PMID: 6428927 Document Number: 230545
The development of a radioreceptor assay for the quaternary anticholinergic drug, oxyphenonium, in plasma is reported. It is based on competition between this drug and 3H-dexetimide for binding to muscarinic receptors. After ion pair extraction and reextraction, the drug can be determined in plasma at concentrations down to a value of 100 pg/ml. This permits pharmacokinetic studies to be made after inhalation of oxyphenonium.