Chlorpropamide hepatotoxicity: report of a case and review of the literature
Schneider, H.L.; Hornbach, K.D.; Kniaz, J.L.; Efrusy, M.E.
American Journal of Gastroenterology 79(9): 721-724
1984
ISSN/ISBN: 0002-9270 PMID: 6475904 Document Number: 230544
Chlorpropamide, a sulfonylurea compound used in the treatment of diabetes mellitus, type II, has been implicated as the cause of untoward reactions involving the hematopoietic, cutaneous, and gastrointestinal systems. The hepatotoxic reactions induced by this drug generally present as hepatocanalicular cholestatic reactions, in contrast to the hepatocellular reactions induced by the older sulfonylurea compounds. An unusual presentation of chlorpropamide toxicity, presenting as a mixed hepatocanalicular reaction, is reported, along with a review of the literature.