Bioavailability of two oral formulations of triazolam using radioreceptor assay
Lapka, R.; Cepeláková, H.; Rejholec, V.; Franc, Z.
Die Pharmazie 41(4): 256-257
1986
ISSN/ISBN: 0031-7144 PMID: 3725869 Document Number: 280113
The radioreceptor assay (RRA) was used to quantitate plasma triazolam concentrations in eight female volunteers following single 0.5 mg doses of two tablet formulations in a cross-over study. Bioavailability in terms of area under the plasma concentration versus time curve (AUC0 infinity), maximum plasma concentration (Cmax), time to maximum (tmax), and mean residence time (MRT) was not statistically significantly different from one formulation to the other.