Effect of hydrocortisone and desoxycorticosterone on some reductases, esterases and synthetases
Tancheva, L.; Stoytchev, T.
Acta Physiologica et Pharmacologica Bulgarica 10(4): 59-63
1984
ISSN/ISBN: 0323-9950 PMID: 6442956 Document Number: 229379
Corticosteroids, applied in single high doses, inhibit the activity of mixed function oxidases. Their effect on other drug-metabolizing enzyme systems was studied in rats. Hydrocortisone (HC) and deoxycorticosterone (DOCA), applied in a single dose of 50 mg/kg, do not change the activity of the liver microsomal NADPH-dependent neotetrazolium reductase. HC inhibits the intestinal acetylsalicylic esterase B, whereas DOCA does not change it significantly. This effect should be borne in mind when combining corticosteroids with acetysal. No significant changes are observed in the activity of liver esterase A under the effect of the 2 corticosteroids. DOCA inhibits the liver cytosol glutathione-S-transferase. The reduced enzyme activity of the liver microsomal UDP-glucuronyl-transferase by the 2 corticosteroids and of the glutathione-S-transferase by HC is manifested only as an insignificant tendency.