Effect of hydrocortisone on RNA synthesis in the liver of rats of different ages
Martin, R.; Martin, G.; Muradian, K.K.
Problemy Endokrinologii 29(3): 65-67
1983
ISSN/ISBN: 0375-9660 PMID: 6191320 Document Number: 216709
Hydrocortisone effect on the transcription intensity of several RNA syntheses in the liver of rats of different age was studied in vivo and in vitro. It was shown that hydrocortisone injection to young and adult animals leads to marked stimulation of RNA synthesis in hepatocytes, manifested in increased specific radioactivity of RNA fractions or enhanced RNA-polymerase A and B activities. In old rats the intensity of the nuclear precursor synthesis of ribosome RNA is also significantly grows under hormone influence, whereas the informative RNA intensity does not markedly change.