Use of several precursors for in vivo lipid synthesis in different animal organs and tissues in the neonatal period
Snitinskiĭ, V.V.; Ianovich, V.G.; Goĭsaliuk, S.V.
Biokhimiia 49(10): 1656-1660
1984
ISSN/ISBN: 0320-9725 PMID: 6518186 Document Number: 228190
The radioactivity of total lipids and their classes synthesized from the 14C-labeled palmitate, glucose, lactate, pyruvate, oxybutyrate and alanine in the liver, lungs, skeletal muscle, subcutaneous adipose tissue and jejunal mucosa of one- and five-day-old piglets was investigated. The lipid synthesis from the majority of the precursors under study in animal organs and tissues decreases in the following order: lungs greater than liver greater than jejunal mucosa greater than adipose tissue greater than skeletal muscle. Incorporation of the label from [1-14C]palmitate and [3-14C]oxybutyrate into the lipids occurs more intensively than that from other labeled compounds. In piglets of one to five days of age, the expenditure of [1-14C]palmitate and [1-14C] glucose for lipid synthesis in most organs and tissues decreases, whereas that of [1-14C]alanine and [1-14C]pyruvate increases. The label from [1-14C]palmitate and [1-14C]glucose is mainly localized in the liver, lungs, muscular tissue and jejunal mucosa phospholipids, while that in the adipose tissue--in acylglycerols. The amount of phospholipids in most organs and tissues of one-day-old animals is greater, while that of acylglycerols smaller in comparison with the five-day-old ones. There is a correlation between the synthesis of individual lipid classes and the degree of functional maturity of organs and tissues of young animals.