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Fibroblast precursors in normal and irradiated mouse hematopoietic organs

Friedenstein, A.J.; Gorskaja, J.F.; Kulagina, N.N.

Experimental Hematology 4(5): 267-274

1976

ISSN/ISBN: 0301-472X
PMID: 976387
Document Number: 100422
Using the in vitro colony assay, clonogenic fibroblast precursor cells (CFU-F) were detected in the bone marrow, spleen and thymus from adult mice. The survival curve for CFU-F of mouse bone marrow irradiated in vitro has a D0 of 220 R. Regeneration of bone marrow CFU-F after whole-body irradiation with 150 R is characterized by a marked secondary loss and post-irradiation lag and dip, lasting 6 days, followed by return to normal values by about the 25th day. This pattern of post-radiation recovery of CFU-F is similar to that of the hemopoietic stem cells. In addition, during the first 6 h following irradiation the number of CFU-F increased approximately 2-fold.

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