Mechanism of the formation of nitrosyl complexes of non-heme iron in animal tissues in vivo
Varich, V.I.; Vanin, A.F.
Biofizika 28(6): 1055-1060
1983
ISSN/ISBN: 0006-3029 PMID: 6317057 Document Number: 208976
Further investigations were carried out into the formation mechanism of nitrosyl complexes of non-heme iron (complexes 2.03) in rat liver and blood at intrauterine injection of aqueous solutions of nitrosyl complexes of iron with cysteine, thiosulphate, phosphate, ATP and hydroxyl, as well as at keeping the animals on nitrite and iron diet. It has been found that 5-6 hours after the injection of iron nitrosyl complexes with cysteine/the shape of ESR signal with gav = 2.03 in the liver becomes identical to the shape of the signal obtained after adding nitrite and iron to the animal food. Therefore it is assumed that in spite of different methods of induction, the 2.03 complexes formed in these experiments are identical in structure and localization. The assumption was proved as to initial formation of Fe-NO in the blood with subsequent transition to SH-groups of liver proteins. It is suggested that complexes 2.03 in vivo are concerned with a specific type of protein.