Efficacy of benzimidazole carbamate on an intestinal fluke co-infected with nematodes
Waikagul, J.; Watthanakulpanich, D.; Muennoo, C.; Maipanich, W.; Sa-nguankiat, S.; Phubampen, S.
Journal of the Medical Association of Thailand 88(2): 233-237
2005
ISSN/ISBN: 0125-2208 PMID: 15962676 Document Number: 2258
The efficacy of a single dose of benzimidazole, drugs commonly used for the treatment of Ascaris and hookworm, was evaluated against one of the tiny-sized intestinal flukes, Haplorchis sp in the endemic area where mixed infections of roundworms and flatworms existed At day 7 after treatment, albendazole (400 mg) induced 42.5% cure rate, mebendazole (500 mg) a cure rate of 32.4%, on the other hand, praziquantel (40mg/kg) gave 94.6% cure rate and the placebo at 15.9%. At the single dose, benzimidazole could not completely expelled the haplorchid; but could reduce one third to two fifth of the infection, similar to the drugs efficacy against Trichuris infection.
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