Unfavorable neonatal outcome after intraamniotic injection of methylene blue
McEnerney, J.K.; McEnerney, L.N.
Obstetrics and Gynecology 61(3 Suppl): 35s-37s
1983
ISSN/ISBN: 0029-7844 PMID: 6823393 Document Number: 220963
A case is presented in which methylene blue dye was injected intraamniotically to confirm rupture of the membranes. Significant neonatal morbidity occurred as a direct result of the methylene blue dye injection. A syndrome of toxic side effects is described including hemolytic anemia, hyperbilirubinemia, and methemoglobinemia. The metabolic process is discussed. The authors suggest discontinuing the intraamniotic injection of methylene blue dye as a diagnostic aid.