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DNA polymorphism adjacent to human apoprotein A-1 gene: relation to hypertriglyceridaemia

Rees, A.; Shoulders, C.C.; Stocks, J.; Galton, D.J.; Baralle, F.E.

Lancet 1(8322): 444-446

1983

ISSN/ISBN: 0140-6736
PMID: 6131168
Document Number: 218252
Polymorphism in a DNA sequence was observed on the 3'-flanking region of the human apoprotein-A-1 gene. The frequency of the heterozygous state in a healthy control population (n = 73) is around 0.05. However, 12 (frequency 0.34) out of 35 subjects with hypertriglyceridemia had the polymorphic site, and 2 were homozygous for this variant. The mutant allele may constitute a linkage marker for some abnormality within the apoprotein-A-1 gene, affecting either expression of or some minor structural modification of the A-1 apoprotein, that may predispose to hypertriglyceridemia.

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Xu, H.J.; Zhou, H.Y.; Hu, S.X.; Pan, X.R. 1989: Cloning of apoprotein AI gene and observation on DNA polymorphism of apoprotein AI/CIII gene-loci in genomic library from a liver of Chinese Chinese Medical Journal 102(3): 169-173
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Igase, M.; Miki, T. 2006: Relation between gene polymorphism and acute coronary syndrome Nihon Rinsho. Japanese Journal of Clinical Medicine 64(4): 647-650
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Hwang, I.; Gottlieb, P.D. 1997: The Bop gene adjacent to the mouse CD8b gene encodes distinct zinc-finger proteins expressed in CTLs and in muscle Journal of Immunology 158(3): 1165-1174
Veresh, I.; Taysik, T.; Frish, A.; Khollan, S. 1985: Relation between human erythrocytic polymorphism and immunologic reactivity to tetanus, typhoid and smallpox antigens Gematologiia i Transfuziologiia 30(11): 7-12
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Baturin, A.K.; Sorokina, E.I.; Pogozheva, A.V.; Peskova, E.V.; Makurina, O.N.; Tutel'ian, V.A. 2014: Regional features of obesity-associated gene polymorphism (rs9939609 FTO gene and gene Trp64Arg ADRB3) in Russian population Voprosy Pitaniia 83(2): 35-41
Maliarchuk, B.A.; Perkova, M.A.; Derenko, M.V. 2011: Polymorphism of 5' promotor region of mitochondrial gamma-DNA-polymerase gene in human populations Molekuliarnaia Biologiia 45(5): 924-926
Ji, Y.-h.; Ruan, Q.; Lu, Y.; Qi, Y.; He, R.; Liu, Q.; Chen, S.-r.; Ma, Y.-p. 2004: Polymorphism analysis of human cytomegalovirus UL148 gene in low passage clinical isolates Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 18(2): 154-157
Sokhin, A.A. 1975: Systematization of factors conditioning the relation between susceptibility to infectious diseases and the antigenic polymorphism of human blood groups Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 4: 23-28
Sunthornthepvarakul, T.; Kitvitayasak, S.; Ngowngarmaratana, S.; Konthong, P.; Deerochanawong, C.; Sarinnapakorn, V.; Phongviratchai, S. 1999: Lack of association between a polymorphism of human thyrotropin receptor gene and autoimmune thyroid disease Journal of the Medical Association of Thailand 82(12): 1214-1219
Skriabin, B.V.; Voskoboĭnik, N.I.; Ose, A.I.; Gindilis, V.M. 1989: Study of polymorphism in human rRNA gene clusters. Population and familial analysis of basic types of RFLP Genetika 25(8): 1488-1498
Chagas, B.ár.S.; Gurgel, A.P.A.D.; da Cruz, H.L.A.; Amaral, C.M.M.; Cardoso, M.V.; Silva Neto, J.d.C.; da Silva, L.A.ôn.F.; de Albuquerque, E.ên.M.B.; Muniz, M.T.C.; de Freitas, A.C. 2013: An interleukin-10 gene polymorphism associated with the development of cervical lesions in women infected with Human Papillomavirus and using oral contraceptives Infection Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases 19: 32-37
Turetskaya, R.L.; Udalova, I.A.; Kuprash, D.V.; Terskikh, A.V.; Nedopasov, S.A. 1991: Use of synthetic oligonucleotides for studying gene structure and polymorphism: human genes encoding tumor necrosis factors and their receptors Nucleic Acids Symposium Series 24: 275
Schalasta, G.; Roth, B. and Gisela Enders 2002: Rapid Ryping of the Codon 129 Polymorphism of the Human Prion Protein Gene by Combined Real-Time PCR and Melting Curve Analysis Clinical Laboratory 48(1-2): 25-30
Wu, Y.; Zhang, Q.; Tang, H. 1997: Detection of p53 gene mutations in human gestational trophoblastic neoplasia by polymerase chain reaction-single strand conformational polymorphism techniques Hunan Yi Ke Da Xue Xue Bao 22(4): 338-340
Tsuge, A.; Uchida, H.; Ishimoto, G. 1987: Erythrocyte S-formylglutathione hydrolase polymorphism in Japanese and the relation to erythrocyte esterase D polymorphism Nihon Hoigaku Zasshi 41(2): 93-96
Babaev, V.R.; Osis, I.L.; Vikhert, A.M. 1988: Cytophotometric analysis of the apoprotein B content of sections of the human aorta Biulleten' Eksperimental'noi Biologii i Meditsiny 105(6): 743-746