Synthesis and analgesic effect of 2-aryliminomethylquinolines
Hagen, V.; Dove, B.; Morgenstern, E.; Labes, D.; Göres, E.; Tomaschewski, G.; Geisler, G.; Franke, C.
Die Pharmazie 38(7): 437-439
1983
ISSN/ISBN: 0031-7144 PMID: 6634910 Document Number: 209095
2-Aryliminomethylquinolines were synthesized by the condensation of quinoline-2-carbaldehyde with the corresponding anilines. The compounds were evaluated for analgesic activity using the acetic acid writhing test. Some of them showed significant inhibition of the writhing syndrome. The most potent compound 3b was approximately as active as aminophenazone in the writhing and the hot-plate method.