Effect of insulin on the transformation of BALB/3T3 cells by X-ray irradiation
Umeda, M.; Tanaka, K.; Ono, T.
Gan 74(6): 864-869
1983
ISSN/ISBN: 0016-450X PMID: 6365675 Document Number: 204457
The effects of triiodothyronine (T3), hydrocortisone, and insulin on X-ray-induced transformation of BALB/3T3 A31-1-1 cloned cells were examined. Under the experimental conditions employed, the addition of 10(-7) M T3 or hydrocortisone to the serum-containing medium had little effect on the transformation. In contrast, the addition of insulin dramatically enhanced the transformation. The effect of insulin was concentration-dependent up to 10 micrograms/ml and was consistently observed with X-rays at various doses.