The influence of oral immunization on local and systemic immune responses to heterologous antigens
Stokes, C.R.; Newby, T.J.; Bourne, F.J.
Clinical and Experimental Immunology 52(2): 399-406
1983
ISSN/ISBN: 0009-9104 PMID: 6345040 Document Number: 201619
Oral immunization with 25 mg/day of ovalbumin resulted in a number of changes in non-specific immune responsiveness, including increases in antibody produced to T-dependent but not T-independent antigens and the abrogation of tolerance induced by both oral and i.v. routes. The effect was transient, sex- and strain-dependent. Evidence suggests that it is a consequence of cell-mediated immunity to the oral immunogen.
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