Dynamics of acute and memory mucosal and systemic immune responses against HIV-1 envelope following immunizations through single or combinations of mucosal and systemic routes
Srivastava, I.; Goodsell, A.; Zhou, F.; Sun, Y.; Burke, B.; Barnett, S.; Vajdy, M.
Vaccine 26(22): 2796-2806
2008
ISSN/ISBN: 0264-410X PMID: 18440102 DOI: 10.1016/j.vaccine.2007.11.083Document Number: 200907
In this study, immunizations at 2 weeks vs. 6 weeks intervals, with an HIV-1 envelope protein in adjuvants, through intra-nasal (IN), intra-muscular (IM), IN followed by IM (IN/IM) and IM/IN, were compared for induction of mucosal and systemic immune responses. IN/IM immunizations at 2, but not at 6, week intervals induced the highest mucosal and systemic immune responses compared to other immunization routes. Following a resting memory phase, IN boosting of IN/IM-immunized mice, compared to IM-boosting of IM-immunized mice, induced increased IgA responses. Thus, depending on the immunization intervals, IN/IM may be more effective than IM immunizations for short- and long-term immunity.
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