Suppression of humoral immune responses in mice by antigens derived from Trichomonas vaginalis
Chao, D.; Wong, S.R.; Ng, H.T.
Proceedings of the National Science Council Republic of China. Part B Life Sciences 13(3): 171-175
1989
ISSN/ISBN: 0255-6596 PMID: 2594864 Document Number: 341877
The occurrence of immunosuppression in mice inocubated with antigens prepared from Trichomonas vaginalis was investigated in this study. One hundred and fourteen BALB/c mice with half of each sex were divided into 19 groups and inoculated with different antigen preparations before of after sheep red blood cell (Srbc) immunization. Antigen preparations included live T. vaginalis (LTV), excretory and secretory products (ESP), and freeze and thaw antigens (FTA). The immunosuppressive effects of these T. vaginalis-derived antigens were demonstrated by the decrease of hamagglutination titers to Srbc. Results indicated that all three antigen preparations exhibited immunodepressive potentials in the primary and secondary responses to Srbc. Among them, FTA showed the highest inhibitory effect. The duration of the effect persisted for 21 days. The immunosuppressive effect was not observed for antigens which were given after Srbc injection.