Effect of opiates on Ca2+ transport in synaptosomes
Zaĭtsev, S.V.; Porodenko, N.V.; Varfolomeev, S.D.
Bioorganicheskaia Khimiia 9(6): 849-851
1983
ISSN/ISBN: 0132-3423 PMID: 6679785 Document Number: 200905
Potassium-stimulated uptake of Ca2+ by nerve-ending fractions from rat brain (synaptosomes) is inhibited by morphine and [D-Ala2, D-Leu5]enkephalin. This effect develops significantly within 1 minute. The opiates do not affect the Ca2+ efflux from the synaptosomes. Naloxone, the opiate antagonist, does not reverse the effect of morphine on synaptosomal Ca2+ uptake, and in this respect itself acts similarly to morphine).
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