Effect of M-and N-cholinolytics on the content of Ca2+ in synaptosomes and metabolism of phosphoinositols in the rat brain
Sukhovskaia, T.A.; Semenov, E.V.; Krylov, S.S.
Voprosy Meditsinskoi Khimii 29(5): 51-54
1983
ISSN/ISBN: 0042-8809 PMID: 6649533 Document Number: 214101
M-cholinolytics benactyzine and glypine increased a permeability of neurone membranes for Ca2+, producing the ion accumulation in synaptosomes. N-cholinolytic thropacin did not exhibit this effect and diphacyl caused similar to the M-cholinolytics but only slight effect on the Ca2+ content. The M-cholinolytics increased phosphoinositol turnover in rat brain, while the N-cholinolytics decreased its metabolism. These data obtained suggest that the M-cholinolytics interact selectively with phosphoinositols of neurone membranes affecting the affinity of phosphoinositols to two-valent cations and elevating the ability of Ca2+ to penetrate across neuronal membranes.