The interaction of tumor localizing porphyrins with collagen and elastin
Musser, D.A.; Wagner, J.M.; Datta-Gupta, M.
Research Communications in Chemical Pathology and Pharmacology 36(2): 251-259
1982
ISSN/ISBN: 0034-5164 PMID: 7100629 Document Number: 188732
The interaction of a series of tumor localizing porphyrins with bovine and porcine collagen and elastin was determined. All the porphyrins studied bound to acid soluble and insoluble collagen, but to differing extents, as well as to elastin. The extent of binding to acid soluble collagen was greater than that to insoluble collagen. The major consequence of this association was a marked decrease in the solubility of the acid soluble collagen suggesting stabilization of the fibrillar structure of the collagen had occurred. Evidence was also obtained indicating the porphyrins could bind to collagen .alpha.-chains. The relevance of these findings to porphyrin localization is discussed.