Synthesis and local anesthetic activity of some n-beta-diethylaminoethylnaphthalimides
Da Settimo, A.; Primofiore, G.; Livi, O.; Tonetti, I.; Tellini, N.; Bianchini, P.
Il Farmaco; Edizione Scientifica 37(2): 105-115
1982
ISSN/ISBN: 0430-0920 PMID: 7067806 Document Number: 188491
Some N-beta-diethylaminoethylnaphthalimides substituted in the 3 or 3 and 4 positions with alkoxy or butylamino groups or with alkoxy and amino groups (III) have been synthesized by reaction of the appropriate naphthalic anhydride with N,N-diethylethylenediamine. Some compounds (III) were tested to evaluate their anesthetic activity: compounds (III e) and (III f) have been shown to have a greater activity than lidocaine.