Effects of corticosteroids on the soluble creatine phosphokinase of the skeletal muscle of rats of various ages
Srivastava, S.K.; Kanungo, M.S.
Research Communications in Chemical Pathology and Pharmacology 35(2): 325-328
1982
ISSN/ISBN: 0034-5164 PMID: 7071416 Document Number: 187715
Effects of adrenalectomy, hydrocortisone and cortisone on the activity of creatine phosphokinase of the skeletal muscle of 7-, 30-, and 80-week old male rats were studied. The specific activity of the enzyme was the highest in the young and decreased in adult and old rats. However, its activity increased with age when expressed as units/mg DNA. Adrenalectomy decreased the activity in the young, but not in the adult and old rats. Hydrocortisone induced it in the young and old rats, but not in the adults rats. Cortisone induced it in the young and to some extent in the adult rats, but not in the old rats. The magnitude of induction was higher in the young rats with both hormones. Induction of enzyme was actinomycin D sensitive.