Creatinine phosphokinase and adenylate kinase activities in skeletal muscle of malignant hyperthermia susceptible patients
Oku, S.; Britt, B.A.
Masui. Japanese Journal of Anesthesiology 30(8): 819-825
1981
ISSN/ISBN: 0021-4892 PMID: 6275140 Document Number: 180917
Creatinine phosphokinase (CPK) and adenylate kinase (AK) activities were measured in vastus lateral muscle of 26 subjects divided into 3 groups by the caffeine contracture test. Malignant hyperthermia reactive (MH-R) was designated as those whose caffeine specific concentrations without and with halothane were < 4.05 mM and < 1.2 mM, respectively, and malignant hyperthermia intermediate, those whose caffeine specific concentrations without and with halothane were > 4.05 mM and < 1.2 mM, respectively. AK activity was statistically higher than normal in MH-R. CPK activity showed the same level in 3 groups. Malignant hyperthermia had no defect in AK of skeletal muscle. The higher AK activity in MH-R could have been induced as a compensation mechanism by chronic depletion in ATP or by an increased energy demand.