Pathogenesis on the experimental infections of Candida albicans in chickens
Tsai, S.S.; Chang, C.F.
Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 15(3): 227-232
1982
ISSN/ISBN: 0253-2662 PMID: 7140438 Document Number: 186956
Systemic candidiasis was induced in chicks by both intravenous and subcutaneous injections of viable Candida albicans. However, infection could not be produced by intratracheal or oral injections. Pathologically, necrotic foci were found in the brain, heart, and spleen but not in the liver, kidney, and lungs of the diseased chicks. Numerous segments of the pseudomycelium were seen in the necrotic areas which were surrounded by foreign body giant cells. Pure cultures of the agent were successfully isolated from the necrotic tissues. C. albicans seemed to have an affinity for the brain and heart in fowls instead of the kidney which is focus of infections in rabbits.