Intravaginal infection of the rat with Trichomonas vaginalis and Candida albicans. An experimental model for chemotherapy
Meingassner, J.G.; Georgopoulos, A.; Patoschka, M.
Tropenmedizin und Parasitologie 26(4): 395-398
1975
ISSN/ISBN: 0303-4208 PMID: 1216328 Document Number: 92597
Ovariectomised and oestrogen premedicated rats were infected intravaginally, with first C. albicans and then with T. vaginalis. Under these conditions infections with T. vaginalis could be established with more reliability than when using axenically-cultivated T. vaginalis alone. This mode of infection is easily reproduced, and it allows the performance of chemotherapeutic tests on small groups of laboratory animals. Such tests were carried out with Metronidazole, Tinidazole and Nifuratel.