Pathogenesis of acute avian malaria. I. Immunologic reactions associated with anemia, splenomegaly, and nephritis of acute Plasmodium gallinaceum infections of chickens
Soni, J.L.; Cox, H.W.
American Journal of Tropical Medicine and Hygiene 23(4): 577-585
1974
ISSN/ISBN: 0002-9637 PMID: 4847038 Document Number: 76353
Anaemia with splenic enlargement was produced in normal chickens within 24 hours by intravenous injection of malarious chicken plasma that contained high titres of hemagglutinin, serum antigen, and antibody. A similar anaemia and splenic engorgement resulted in normal birds injected with eluates from the washed blood cells of malarious chickens. Within 24 hours, the malarious plasma produced an acute glomerulonephritis similar to that which had been observed on the 5th day of infection. The concurrent presence of the hemagglutinin, serum antigen, and its antibody in the injected plasma, and the failure of the plasma to produce nephritis in immunized chickens, suggested that immune substances might be causal in acute malarial anaemia and nephritis.