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Activity of di-N-hydroxyquinoxaline and depot-sulfanilamide derivatives in experimental NAG infection

Avtsyn, A.P.; Pershin, G.N.; Trager, R.S.; Shakhlamov, V.A.; Padeĭskaia, E.N.

Biulleten' Eksperimental'noi Biologii i Meditsiny 93(5): 76-78

1982

ISSN/ISBN: 0365-9615
PMID: 7093514
Document Number: 185374
In experiments in vitro dioxidineeee was highly effective as regards all the test cultures of NAG-vibrios. The MTC ranged within 1 to 62 micrograms/ml. Bactericidal action of the drug became manifest at concentrations from 4 to 250 micrograms/ml. The derivatives of di-N-oxide quinoxaline, dioxidin and quinoxidine exerted a chemotherapeutic effect and sterilizing action in experimental NAG-infection. The action of the drugs was potentiated upon combined use with lysozyme. As far as depo-sulfanilamides are concerned, sulfalenee was little active, while sulfamonomethoxine ineffective in experimental NAG-infection.

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