Ascorbigen and its derivatives--depot preparations of ascorbic acid
Bukin, I.V.; Plikhtiak, I.L.; Draudin-Krylenko, V.A.; Iartseva, I.V.; Orlova, L.M.
Bioorganicheskaia Khimiia 13(4): 539-545
1987
ISSN/ISBN: 0132-3423 PMID: 3606674 Document Number: 293991
New derivatives of 2-C-/(indolyl-3)methyl/-beta-L-threo-L-glycero-3-hexulofuranosono- 1,4-lactone, vis. 1'-ethylascorbigen, 1'-benzylascorbigen and 1',2'-dimethyl-5'-methoxyascorbigen were obtained. In aquous solutions at physiological temperature and pH values ascorbigens disintegrate rather rapidly to yield L-ascorbic acid, the rate of the latter's formation depending on the substituent in the indole nucleus and increasing with growth of pH and temperature. Intraperitoneal injection of 1'-methylascorbigen to mice leads to steady rise of L-ascorbic acid level in blood plasma.