Interaction between hydroquinone and ascorbic acid derivatives: quenching effect of organic solvents
Satoh, K.; Sakagami, H.; Terasaka, H.; Ida, Y.; Fujisawa, S.
Anticancer Research 20(3a): 1577-1581
2000
ISSN/ISBN: 0250-7005 PMID: 10928073 Document Number: 525338
The interaction between hydroquinone (HQ) and ascorbic acid analogs was investigated. Semiquinone radicals (SQcntdot) generated by HQ were comparably scavenged by ascorbic acid, sodium ascorbate and ascorbate 6-palmitate, but much less efficiently by ascorbate 2,6-dipalmitate. Organic solvents, such as dimethysulfoxide (DMSO) or ethanol, which are utilized for solubilization of water-insoluble analogs, ascorbate 6-palmitate and ascorbate 2,6-dipalmitate, also scavenged SQcntdot. DMSO scavenged the SQcntdot more efficiently than ethanol. This suggests the importance of considering such a quenching, effect of organic solvent in the study of the interaction between HQ and antioxidants. The involvement of the ascorbate radical for cytotoxicity induction is discussed.