Relation between the status of cellular immunity and pharmacologic immunocorrection of the wound process by phytohemagglutinin in rabbits
Bol'shakov, I.N.; Lindner, D.P.; Poberiĭ, I.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 91(6): 733-736
1981
ISSN/ISBN: 0365-9615 PMID: 7272493 Document Number: 176672
Altogether 183 C57BL/6 mice were used to determine the optimum dose of phytohemagglutinin (PHA) to be equal to 3 microgram/g liniment tela, which reduced the time of wound healing by 33%. Experiments on 255 heterobred rabbits of both sexes revealed that the natural animal population could be distributed into three groups according to delayed type hypersensitivity (DTH) to PHA: highly sensitive, moderately sensitive and poorly sensitive, in a ratio of 1:1, 5:1. Microscopic, cytological and histological analyses have demonstrated that PHA exerts a selective therapeutic effect on wound healing. The reduction of the time required for wound healing by 38% and positive changes in cellular dynamics of inflammation have been observed only in the animals with a weak DTH to PHA. The PHA intracutaneous test is recommended for selection of patients being in want of pharmacological correction of wound healing.