Immunocorrection with pentaglobin in wound infection and burn disease
Karlov, V.A.; Belotskiĭ, S.M.; Alekseev, A.A.; Gutsu, E.V.; Dikovskaia, E.S.; Filiukova, O.B.; Lukovnova, T.N.; Borisova, T.G.; Elagina, L.V.
Antibiotiki i Khimioterapiia 36(5): 42-45
1991
ISSN/ISBN: 0235-2990 PMID: 1953173 Document Number: 374288
Patients with wound infections and extended burns were treated with pentaglobin (Biotest-Pharma), a serum preparation containing high concentrations of immunoglobulin M. The use of the preparation at early stages after surgical operations in the patients with wound infections or at the beginning of active surgical treatment of the patients with burns decreased the terms of the body temperature normalization as well as normalization of the immunological, hematological and biochemical indices. The most pronounced efficacy of pentaglobin was observed in the patients with severe microbial toxemia. A scheme for pathogenetic immunocorrection of wound infections and burns was developed. It is based on simultaneous recording of intensity of immunological responses in peripheral blood and intensity of protective reactions in wound tissues.