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Assessment of the progestagenic and oestrogenic activity of compounds by their effect on implantation in rats with diapausing embryos

Cochrane, R.L.; Smalstig, E.B.; Bennett, D.R.; Shaar, C.J.

Journal of Reproduction and Fertility. Suppl 29: 187-190

1981

ISSN/ISBN: 0449-3087
PMID: 6939864
Document Number: 175763
The oestrogenic, progestagenic and mixed oestrogenic--progestagenic activities of various compounds were assessed by their effects on implantation and its delay in the ovariectomized rat. Progesterone, norgestrel and 17 alpha-(2-butynyl)-17 beta-hydroxyestra-4,9,11-trien-3-one (R3852-3) were investigated. Progesterone and norgestrel proved to be progestagens with little or no inherent oestrogenic activity, while R3852-3 appeared to have both progestagenic and oestrogenic activity. The oestrogenic activity of R3852-3 was verified by using an Allen--Doisy type of assay system.

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