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Characteristics of the effect of implantation of the human ApoA1 gene on the condition of hepatocytes in rats of varying age

Frol'kis, V.V.; Kordium, V.A.; Kul'chitskiĭ, O.K.; Novikova, S.N.; Gulaia, N.M.; Irolov, D.V.; Kobzar', A.L.; Potapenko, R.I.; Paramonova, G.I.; Bogatskaia, L.N.; Muradian, K.K.

Ukrains'kyi Biokhimichnyi Zhurnal 71(4): 71-74

1999

ISSN/ISBN: 0372-3909
PMID: 10791061
Document Number: 508740
The results obtained show the essential changes in functional state of hepatocyte's plasmatic membrane due to the implantation of human ApoA1 gene to the rat liver. The changes in phospholipid composition, hyperpolarization, increase in activity of membrane bound enzymes, cytochrome P-450 and biosynthesis of liver total proteins have been found. The essential changes characterizing cell effect were more marked in the adult rats, and membrane effect in the old ones.

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