Top Abstract Purchase Related
Home
>
Node
>
Subnode

Assessment of new compounds for antiprogestational activity

Mehrotra, P.K.; Prashad, M.; Seth, M.; Bhaduri, A.P.; Kamboj, V.P.

Indian Journal of Experimental Biology 17(12): 1317-1319

1979

ISSN/ISBN: 0019-5189
PMID: 161551
Document Number: 144827
Synthetic analogs [51] of amphenone were evaluated for probable antiprogestational activity against progesterone-induced deciduoma formation in the uterus of immature rats. Of these, 5 compounds exhibited potentiality. Only 2 of the active compounds inhibited (partially) glandular proliferation of the uterine endometrium in immature rabbits (Clauberg assay) and prevented implantation by more than 50% in mated hamsters. None of the active compounds possessed estrogenic/antiestrogenic activities. These results highlight the dissimilarity of antiprogestational activity in different bioassays.

Document emailed within 1 workday
Secure & encrypted payments

Cochrane, R.L.; Smalstig, E.B.; Bennett, D.R.; Shaar, C.J. 1981: Assessment of the progestagenic and oestrogenic activity of compounds by their effect on implantation in rats with diapausing embryos Journal of Reproduction and Fertility. Suppl 29: 187-190
Readio, J.; Meola, R.; Jurd, L. 1987: Assessment of six benzyl-1,3-benzodioxole compounds for anti-juvenile hormone activity in Culex pipiens Journal of the American Mosquito Control Association 3(1): 15-19
Tamaya, T.; Motoyama, T.; Ohono, Y.; Ide, N.; Turusaki, T.; Okada, H. 1979: Local progestational and antiprogestational effects of steroids and their metabolites on the rabbit uterus Nihon Funin Gakkai Zasshi 24(1): 48-51
Cechinel Filho, V.; Pinheiro, T.; Nunes, R.J.; Yunes, R.A.; Cruz, A.B.; Moretto, E. 1994: Antibacterial activity of N-phenylmaleimides, N-phenylsuccinimides and related compounds. Structure-activity relationships Farmaco 49(10): 675-677
Avico, U.; Signoretti, E.C.; Di Francesco, R.; Zuccaro, P.; Cingolani, E. 1976: Physical parameters and biological activity of organic compounds. Note III - On the activity coefficient of some barbiturates Bollettino Chimico Farmaceutico 115(3): 242-253
Grasso, S.; Chimirri, A.; Monforte, P.; Fenech, G.; Zappalà, M. 1986: Compounds with potential antitumor activity. IV. Synthesis and antileukemic activity of 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylenediamine Il Farmaco; Edizione Scientifica 41(9): 713-721
Elferink, J.G.; Salemink, C.A. 1975: Relation between structure and muscarinic activity III. Synthesis and cholinergic activity of some-onium compounds related to 2-methyl-4-trimethylammoniomethyl-1,3-dioxolane iodide Arzneimittel-Forschung 25(12): 1858-1860
Wilkinson, R.R. 1984: Technoeconomic and environmental assessment of industrial organotin compounds Neurotoxicology 5(2): 141-158
Pecka, I.; Wiglusz, R.; Sitko, E.; Nikel, G. 2004: Assessment of the emission of volatile organic compounds from polyurethane foams Roczniki Panstwowego Zakladu Higieny 55(2): 181-185
Dwyer, J.T. 2001: An assessment lexicon: assessment of dietary trends, physical activity patterns and nutritional status in the elderly Journal of Nutrition Health and Aging 5(2): 108-112
Kravchenko, L.V.; Levitskaia, A.B.; Kranauskas, A.E. 1986: The enzymes of the metabolism of exogenous compounds in the comparative assessment of the toxicity of trichothecene mycotoxins Biulleten' Eksperimental'noi Biologii i Meditsiny 101(4): 428-431
Molnár, J. 1988: Antiplasmid activity of tricyclic compounds Methods and Findings in Experimental and Clinical Pharmacology 10(7): 467-474
Pashchenko, E.A.; Kolodub, F.A.; Vasilenko, N.M.; Zvezdaĭ, V.I. 1990: Changes in the components of the hydroxylase system of the liver microsomes as a criterion in the assessment of the effects of vat dyes and azo compounds Gigiena Truda i Professional'nye Zabolevaniya (5): 52-54
Gitsu, G.A.; Dudarev, V.G.; Fridman, I.A. 2017: Compounds Mst-84 and Mst-85. Preparation and Investigation of Antihymenolepic Activity Meditsinskaia Parazitologiia i Parazitarnye Bolezni 2: 44-45
Chmel', I.V.; Bibikova, M.V.; Spiridonova, I.A.; Tertov, V.V.; Katlinskiĭ, A.V. 2004: Screening of natural compounds with hypolipidemic activity Antibiotiki i Khimioterapiia 49(8-9): 8-12
Rakitskiĭ, V.N.; Turusov, V.S. 2005: The mutagenic and carcinogenic activity of chemical compounds Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2005(3): 7-9
Ficarra, P.; Ficarra, R.; Tommasini, A.; Fenech, G. 1983: Compounds with potential antitumor activity. II. N,N'-(1-Diadamantandicarboxyamides) Il Farmaco; Edizione Scientifica 38(6): 418-424
Didier, E.S.; Maddry, J.A.; Kwong, C.D.; Green, L.C.; Snowden, K.F.; Shadduck, J.A. 1998: Screening of compounds for antimicrosporidial activity in vitro Folia Parasitologica 45(2): 129-139
Lehmann, D.; Eckardt, R.; Faust, G.; Fiedler, W. 1980: On the synthesis of compounds with beta-adrenergic activity Die Pharmazie 34(5-6): 278-284
Verbina, N.M.; Smirnova, L.S.; Danil'chenko, R.N. 1973: The antibacterial activity of several quaternary ammonium compounds Prikladnaia Biokhimiia i Mikrobiologiia 9(4): 575-578