The enzymes of the metabolism of exogenous compounds in the comparative assessment of the toxicity of trichothecene mycotoxins
Kravchenko, L.V.; Levitskaia, A.B.; Kranauskas, A.E.
Biulleten' Eksperimental'noi Biologii i Meditsiny 101(4): 428-431
1986
ISSN/ISBN: 0365-9615 PMID: 3697491 Document Number: 285502
Moderate clinical, biochemical and hematologic signs of intoxication were observed in mice after single administration of HT-2 toxin (deacetylated derivative of T-2 toxin) in LD50 of 12.75 mg/kg or in 1/5 of LD50 for 7 days. The toxin produced no toxic effect when 1/10 and 1/50 of LD50 were administered for 14 days. With the dose exceeding 1/50 of LD50 a reduction in cytochrome P-450 content, carboxylesterase activity and increased activity of UDP-glucuronosyltransferase and glutathione transferase were recorded. T-2 toxin produced a more pronounced toxic effect, inhibited UDP-glucuronosyltransferase and insignificantly stimulated glutathione transferase activity. Lower HT-2 toxin toxicity is believed to depend on its ability to activate conjugation reactions to a greater extent than T-2 toxin.