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Demonstration of a syncarcinogenic effect of endogenous MuLV, rescued from MNU-induced leukemias, and suboptimal MNU doses in mice

Fey, F.; Ehm, I.; Drescher, B.; Rentz, E.; Seidel, G.

Neoplasma 28(3): 265-269

1981

ISSN/ISBN: 0028-2685
PMID: 6270578
Document Number: 175037
It was demonstrated that the combined action of activated endogenous MuLV isolated from MNU-induced leukemias and suboptimal doses of MNU yields a significantly high incidence of leukemias and tumors. Treatment with one agent alone shows low effects only. The findings were discussed in view of the mechanisms in which viruses and chemical carcinogens interact in a syncarcinogenic processes.

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