Lack of a syncarcinogenic effect of cyclamate in inducing bladder neoplasms by butyl-butanol-nitrosamine in rats
Schmähl, D.; Krüger, F.W.
Arzneimittel-Forschung 22(6): 999-1000
1972
ISSN/ISBN: 0004-4172 PMID: 5068363 Document Number: 5456
Butyl-butanol-nitrosamine was applied in a dosage of 10 mg/kg/day in the drinking water to 40 male Sprague-Dawley rats. After a medium induction time of 400±45 days, animals all died with squamous cell carcinomas of the urinary bladder. The additional application of a high dose of cyclamate (2500 mg/kg/day) did not enhance the bladder cancer inducing effect of the nitrosamine.
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