Inhibitory effect of dihydroergocristine, phenoxybenzamine and propranolol on the hypermotility induced by low doses of ethyl alcohol in mice
Boada, J.N.; Feria, M.; Serrano, M.; Darias, V.
Archivos de Farmacologia y Toxicologia 5(2): 117-122
1979
ISSN/ISBN: 0304-8616 PMID: 119498 Document Number: 153867
Low doses of ethanol give rise to hypermotility, an effect apparently related to central catecholamine release. The nature of the adrenergic receptor involved in this effect has not been studied. As a partial approach to this topic the action of dihydroergocrystine, phenoxybenzamine, l-propranolol and d-propranolol on the ethanol-induced hypermotility was tested in mice. All the cited drugs were able to inhibit the excitatory effect of ethanol. As the effect of propranolol can be attributed to an action independent of .beta.-blockade (its d-isomer also produced inhibition of the stimulating response to ethanol), it appears that .alpha.-receptors are mainly involved in the stimulation effect of ethanol.