Inhibiting effect of domestic, synthetic beta-carotene and ascorbic acid on endogenous carcinogenesis in mice
Sergeeva, T.I.; Vakulova, L.A.; Zhidkova, T.A.; Sergeev, A.V.
Voprosy Meditsinskoi Khimii 38(6): 12-14
1992
ISSN/ISBN: 0042-8809 PMID: 1298116 Document Number: 397716
Carcinogenesis in mice induced by the tryptophane derivative 3-hydroxyanthranilic acid was studied after administration of synthetic beta-carotene and ascorbic acid. The incidence of induced hemoblastoses and hepatomas was decreased 2-fold, while the latent period of their development was, increased in mice on a lifetime feed containing 15 mg/kg of beta-carotene. The anticarcinogenic effect of ascorbic acid added to drinking water was similar to that of beta-carotene. The additive inhibitory influence of beta-carotene and ascorbic acid on endogenous blastomogenesis was not found in mice.